The entire aerosol generated by the nebulization process is injected directly into the plasma.
No spray chamber is used to classify the size of the droplets formed by nebulization, so this technique is 100% efficient. Precision and washout times were significantly improved using this approach. Use of this device also leads to reduced memory effects.
Because the DIN operates at 100% efficiency, a significant solvent load is introduced into the plasma. This can result in increased interferences from molecular compounds formed from solvent constituents.
Because the DIN operates at 100% efficiency, a significant solvent load is introduced into the plasma. This can result in increased interferences from molecular compounds formed from solvent constituents.
Detection limits achieved by this method are equivalent to or better than those obtained by other nebulization techniques.
An advantage of the DIN is its ability to function with micro-size samples. Sample volumes as small as a few microliters can be analyzed, making this approach an ideal solution to many special analytical applications.
However, a major drawback to this device is its intolerance to suspended matter in the sample solution. Transport of sample, which is forced through a microcapillary as part of the nebulization process, can be seriously affected by partial clogging from particles or fibers.
An advantage of the DIN is its ability to function with micro-size samples. Sample volumes as small as a few microliters can be analyzed, making this approach an ideal solution to many special analytical applications.
However, a major drawback to this device is its intolerance to suspended matter in the sample solution. Transport of sample, which is forced through a microcapillary as part of the nebulization process, can be seriously affected by partial clogging from particles or fibers.
This alteration of the sample transport will have a direct impact on the accuracy of the analysis.
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